Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.
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Oxidative degradation of raloxifene may lead to adverse reactions . The oxidative degradation of raloxifene to N-oxide is shown in Figure 3. Oxidative degradation of raloxifene. Please choose your subindustry.
Poster Using different coating technologies to apply a functional film-coating polymer onto drug layered pellets Download. As wet binderit combines powerful binding with no peroxides at all.
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Stability condition 3 mo. Link to reset your password has been sent to your provided E-Mail ID. This graft copolymer with a low viscosity provides additional advantages in other applications such as instant release coating, emulsifier, wetting agent and hydrophilic pore former in sustained release tablets. These peroxides not only limited to binders and disintegrants such as povidone and crospovidone but to other killicoat such as fillers, lubricants and surfactants, can also cause oxidative degradation of sensitive drugs.
Thus, controlling these impurities is important in alleviating the degradants kollicaot enhance the shelf life of drug products.
This study also provides an understanding on controlling the degradation of raloxifene and other drugs alike highly sensitive to peroxides by selecting the appropriate binders or excipients lacking residual peroxides. With increasing amounts of peroxides spiked with hydrogen peroxide the formation of N-oxide increased causing a significant loss inpotency of drug . Industry Please choose your industry. The data from this study demonstrates that PEG-PVA, lacking the inherent residual peroxides as shown in Table 4, curtails the oxidative degradation of raloxifene in the tablets.
The possibilities include the use of antioxidants or smart packaging to alleviate the oxidative degradation [19,20].
Likewise, the tablets with povidone K30 bearing the low peroxide e. MedCrave Group Danforth Rd. Such processing steps can lead to elevated impurity levels.
Cookies help us deliver our services. As wet binderit provides high binding efficiency.
Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs
Click here kollcoat submit your manuscript In addition, PEG covalently bound to polyvinyl alcohol acts kolliicoat an internal plasticizer and provides a high flexibility, thus allowing the polymer to overcome the mechanical stress during manufacturing and storage of dosage forms. Compression profiles of ascorbic acid tablets prepared from the kollicoatt prepared by fluid bed and high shear granulations; the compressions were carried out on each individual samples, hence no statistical data.
MedCrave Group kolllcoat ardent to provide article reprints at an instant affordable Read more Portfolio Overview Focusing on your needs with platform solutions Read. Granule properties such as particle size and compression profile were evaluated, and compared with copovidone and HMPC granules.
Highly flexible film thanks to integrated plasticizer. Download Center Looking for application guides, technical and scientific posters, brochures or technical Information? Composition of raloxifene tablets.
Subindustry Please choose your subindustry. The stability of active ingredients depends on external factors, e. In the high shear mixing, the granules however were densely packed, less porous, and hence were less compressible. HelloYou are logged in with access to additional information. Peroxides, amongst many of the impurities, remain the most challenging in drug development.
Please retry again later. Due to its low viscosity values in aqueous solutions, easy processing in a vast process parameter range is assured.
These impurities may lead to undesired reactions and alter the efficacy of dosages with possibly adverse effects . Kollicoaf noted otherwise, the statistical analysis was not performed as all the data points were a single measurement on each individual samples.
Please login with your username and password. Therefore, the efforts continue to identify the appropriate excipients lacking peroxides, or having significantly low peroxides to alleviate the oxidative degradation. Oxidative degradation has been studied extensively . April 22, Published: The stability data reveal that the peroxide level does not kollicoaat at ambient and accelerated stability conditions.