LUPUS TUMIDUS PDF

Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .

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In summary, LET presents a rare, but distinct, subset of CCLE with characteristic clinical features requiring correlation with histological, photobiological, and laboratory findings, since, taken in isolation, other diagnoses can be indicated. Due to the rarity of cases reported, we emphasize the importance of detailed clinical examination luups by histopathological study since isolated examination may lead to underdiagnosing the disease.

Histologic Diagnosis of Inflammatory Skin Diseases.

Reticular erythematous mucinosis REM — a primitive form of mucinosis that worsens with sun exposure and presents satisfactory response to treatment with antimalarial drugs – should also be listed in the differential diagnosis. What if there is a fourth recurrence? Epidermis showed atrophy of the spinous layer and numerical and volumetric reduction of interpapillary ridges. In our patient, despite already being treated with hydroxychloroquine sulfate, mycophenolate mofetil, and tacrolimus for SLE and lupus nephritis, she developed lesions of LET.

In Jessner’s lymphocytic infiltration of the skin, the development of asymptomatic, papulonodular, nonscarring lesions classically involving the face is unrelated to UV exposure in most of the patients. Untreated chronic cutaneous LE tends to persist, but severity is lessened by strict sun protection and avoidance of nicotine. Because of the latency period in development of positive phototest reactions, it may be difficult for patients to link sun exposure with their skin lesions.

Significant past medical history included systemic lupus erythematosus SLE manifested by polyarticular arthritis, malar rash, photosensitivity, positive serology with anti-nuclear antibody titer of 1: The mean age of the entire group, when reviewed for the study inwas Treatment There are few evidence-based pharmacologic treatments for LET beyond case reports and series.

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Archives of Dermatology Reader’s Choice: There are few evidence-based pharmacologic treatments for LET beyond case reports and series. Chronic cutaneous lupus erythematosus CCLE has polymorphous presentations that may occasionally mimic other clinical conditions, causing diagnostic difficulties. The same group reported interstitial mucin deposition as a further characteristic feature of LET and results of direct immunofluorescence staining as often being negative; however, there was no doubt about LET being a separate subset of CCLE.

InGoerz et al 16 emphasized the extreme photosensitivity as a major characteristic feature of LET and detected a male predominance with the peak of onset from 41 through 50 years of age.

What are the specific features of cutaneous lupus erythematosus? Development of characteristic skin lesions are seen 1 week after UV-A irradiation for 3 consecutive days. We performed an incisional biopsy and stained the sample with hematoxylin-eosin, colloidal iron and Ziehl-Neelsen.

Lupus Erythematosus Tumidus: A Unique Disease Entity

A punch biopsy of her right upper extremity revealed a superficial and deep periadnexal and interstitial infiltrate Figure 3. All initially had complete resolution of skin lesions but there were varying rates of relapses, mostly occurring in spring and summer months approximately 3 weeks following sun exposure.

LET resolves with normal skin, no residual scarring, no hyperpigmentation or hypopigmentation. Create tumivus free personal account to download free article PDFs, sign up for alerts, customize your interests, and more.

Get free access to newly published articles Create a personal account or sign in to: Tuidus erythematosus tumidus—a neglected subset of cutaneous Lupus erythematosus: Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. There can be some overlap. Lupus erythematosus tumidus LET is a photosensitive skin disease characterized by succulent, edematous, and non-scarring plaques.

LE is classified as autoimmuneas it is tumidud with pathogenic antibodies directed against components of cell nuclei in various tissues. You can help Wikipedia by expanding it.

Cutaneous lupus erythematosus | DermNet NZ

Unlike subacute cutaneous lupus erythematosus SCLElupus tumidus presents no residual hypopigmentation. One-third of cases are due to previous drug exposure.

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Author information Copyright and License information Disclaimer. However, in our opinion, there is no doubt about LET being a separate entity that has been neglected in the literature since first being described in Young women are most often affected, and there is no restriction to race or age.

Mucosal lesions may predispose to squamous cell carcinoma. From Wikipedia, the free encyclopedia. Histological features include perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition.

Lupus tumidus is similar to Jessner lymphocytic infiltratein which diagnostic criteria for lupus are absent. Although the patients are clinically identified by a characteristic type of skin lesion, LET has been reported previously in the literature in only a few cases.

Cutaneous lupus erythematosus

The eruption had been present for one week and had occurred several months ago for a similar duration and had resolved without treatment or scarring. Following the five week prednisone taper, she has been without any further eruptions to date.

Discussion LET is a photosensitive skin disease that is characterized by succulent, edematous, lupys plaques. Best Pract Res Clin Rheumatol.

The clinical criteria is met with the presence of erythematosus, thick plates with a smooth and edematous surface on sun-exposed areas that leave no scar after regression. Biopsies of the skin on the left frontal region and of the left nasolabial sulcus suggested the diagnosis of lupus tumidus.

For sex distribution, patients with LET were compared with the control group of patients with other forms of cutaneous LE observed at our department from January 1,tumifus December 31,consisting of 66 male and female patients.

Abstract Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. Retrieved from ” https: